Amyloid Load: A More Sensitive Biomarker for Amyloid Imaging
نویسندگان
چکیده
منابع مشابه
Amyloid imaging for Alzheimer's disease.
INTRODUCTION Biomarkers for Alzheimer's disease (AD) may facilitate early and accurate diagnosis and offer a way to track the effectiveness of new therapies. Amyloid imaging offers an unrivaled ability to visualize the presence and anatomical distribution of fibrillar beta-amyloid (Aβ) pathology non-invasively in living humans. New diagnostic criteria for AD incorporate the use of such biomarke...
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Amyloid-related imaging abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer's disease (AD). Early biomarkers of ARIA represent an important challenge to ensure safe and beneficial effects of immunotherapies, given that different promising clinical trials in prodromal and subjects at risk for AD are underway. The recent demonstration that ...
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Imaging of brain β-amyloid plaques with (18)F-labeled tracers for PET will likely be available in clinical practice to assist the diagnosis of Alzheimer disease (AD). With the rapidly growing prevalence of AD as the population ages, and the increasing emphasis on early diagnosis and treatment, brain amyloid imaging is set to become a widely performed investigation. All physicians reading PET sc...
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Brain positron emission tomography (PET) has also been used over many years to diagnose neurodegenerative diseases, and has advantages over MRI due to its higher sensitivity to detect pathologies at a molecular level. While 18F-fluorodeoxyglucose (FDG) PETCT is an established imaging technique for assisting in the differential diagnosis of Alzheimer’s disease (AD) and other forms of dementia, P...
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The heart is the principal site of involvement in nonhereditary ATTR amyloidosis and a major driver of treatment options and prognosis in hereditary forms of the disease. The goals of cardiac imaging in amyloidosis are to aid diagnosis, provide prognostic information, track disease progression and evaluate response to therapy. Echocardiography has long been the mainstay of cardiac evaluation in...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2018
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.118.210518